As with other μ-opioid agonists, tapentadol may bring about spasms on the sphincter of Oddi, and is thus discouraged for use in patients with biliary tract condition such as both equally acute and Persistent pancreatitis. People who are rapid or ultra fast metabolizers to the CYP2C9, CYP2C19, and CYP2D6 enzymes may not reply sufficiently to tapent